Molecular Glues
Protein degradation agents based on the ubiquitin-proteasome pathway include a part of molecular glues. Molecular glues are a class of small molecule compounds that can induce or stabilize the interaction between proteins. If one of the protein is ubiquitin ligase, molecular glue can cause another protein to undergo ubiquitin modification and degradation through the proteasome pathway, which is similar to PROTAC. However, these molecules are classified as ligand for E3 ligase as functional molecules in subsequent classification. Older drugs, thalidomide, lenalidomide, and pomalidomide, together with CC-90009 and CC-92480 reported later all belong to this category.
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Molecular Glues Related Products (380)
Related Products (380)
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Related Compound Screening Libraries (1)
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NHWL071065
0 ImagesCat. No.: HY-182797CAS No.: 3117340-01-6NHWL071065 is a CRBN-targeting IKZF1/IKZF3 molecular glues degrader. NHWL071065 selectively degrades IKZF1 and IKZF3 in lymphoma cells via the ubiquitin-proteasome pathway. NHWL071065 inhibits the proliferation of lymphoma cells. NHWL071065 downregulates proteins involved in cytoskeleton assembly, cell adhesion and immune regulation in cells, while upregulating proteins related to the type I IFN signaling pathway. NHWL071065 can be used in the research of lymphoma.
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Lenalidomide 5'CH2OH
0 ImagesCat. No.: HY-W584683CAS No.: 2761170-98-1Lenalidomide 5'CH2OH is a molecular glue.
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Pomalidomide-2,6-diazaspiro[3.3]heptane
![Pomalidomide-2,6-diazaspiro[3.3]heptane](https://file.medchemexpress.com/product_pic/hy-w1123955.gif "Click to View Pomalidomide-2,6-diazaspiro[3.3]heptane Product Detail")
0 ImagesCat. No.: HY-W1123955CAS No.: 2226301-50-2Pomalidomide-2,6-diazaspiro[3.3]heptane is a molecular glue.
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Antitumor agent-100
0 ImagesCat. No.: HY-153802CAS No.: 2841750-32-9Antitumor agent-100 is an orally active molecular glue that promotes the PDE3A-SLFN12 interaction and induces cell death. Antitumor agent-100 binds to the catalytic pocket of PDE3A, extends hydrophobic groups to mediate the hydrophobic interaction between PDE3A and SLFN12, and stabilizes the PDE3A-SLFN12 complex. Antitumor agent-100 induces cancer cell apoptosis and inhibits tumor growth in mouse xenograft models. Antitumor agent-100 can be used for the research of cervical cancer.
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VAV1 degrader-4
0 ImagesCat. No.: HY-182765CAS No.: 3119457-09-6VAV1 degrader-4 is a VAV1 molecular glue degrader with a DC50 value of 3.93 nM for VAV1 in Jurkat cells. VAV1 degrader-4 can dose-dependently inhibit the production of IL-2. VAV1 degrader-4 can be used for research on autoimmune diseases.
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GSPT1 degrader-7
0 ImagesCat. No.: HY-174238CAS No.: 3082942-43-3GSPT1 degrader-7 (Example 43) is a molecular glue degrader targeting GSPT1. GSPT1 degrader-7 has an EC50 of 0.2 nM in DF15 multiple myeloma cells. GSPT1 degrader-7 can be used in the study of cancer.
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(R)-PVTX-405
0 ImagesCat. No.: HY-172930BCAS No.: 2991023-13-1(R)-PVTX-405 is a IKZF2 molecular glue degrader with a DC50 of 4.1 nM. (R)-PVTX-405 is the (R)-enantiomer of PVTX-405 (HY-172930). PVTX-405 is an orally active IKZF2 molecular glue degrader that significantly inhibits MC38 tumor growth in mouse tumor xenograft models. (R)-PVTX-405 can be used in cancer-related research.
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JP-2-196 hydrochloride
0 ImagesCat. No.: HY-W854844BJP-2-196 hydrochloride is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 hydrochloride also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 hydrochloride induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride has potential for cancer research (such as prostate cancer and leukemia).
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NEURL1B-IN-1
0 ImagesCat. No.: HY-182008CAS No.: 3068938-30-4NEURL1B-IN-1 is a molecular glue-like NEURL1B degrader with a Kd value of 46.2 nM. NEURL1B-IN-1 binds to Arg422 within the NHR2 domain of NEURL1B, triggers its autoubiquitination and proteasomal degradation, disrupts its interaction with DLL1, and attenuates the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest and apoptosis, and inhibits migration of hepatocellular carcinoma cells. NEURL1B-IN-1 is applicable to research related to hepatocellular carcinoma.
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NUV-244
0 ImagesCat. No.: HY-173599NUV-244 is a molecular glue degrader of PNPLA3 I148M. NUV-244 induces degradation via the ubiquitin-proteasome system involving the E3 ligase BFAR. NUV-244 promotes 26S proteasome-dependent degradation of PNPLA3 I148M. NUV-244 restores lipid droplet morphology and cellular fitness in hepatocytes expressing PNPLA3 I148M. NUV-244 can be used in the research of metabolic dysfunction-associated fatty liver disease.
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Rapamycin-13C,d3-1
0 ImagesCat. No.: HY-W765245Synonyms: Sirolimus-13C,d3-1; AY-22989-13C,d3-1Rapamycin-13C,d3-1 (Sirolimus-13C,d3-1) is the deuterated, 13C-labeled Rapamycin (HY-10219). Rapamycin (Sirolimus; AY 22989) is a potent and specific blood-brain barrier-transmissible mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells. Rapamycin is a molecular glue that binds FKBP12 and mTOR proteins together, thereby inhibiting mTOR kinase activity. Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator, an immunosuppressant.
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ZC9
0 ImagesCat. No.: HY-179123CAS No.: 2757513-79-2ZC9 is a androgen receptor (AR) molecular glue degrader. ZC9 directly binds to AR and inhibits Dihydrotestosterone-induced nuclear translocation of AR. ZC9 promotes AR degradation via the ubiquitin-proteasome system and suppresses AR transcriptional activity. ZC9 significantly decreases the mRNA levels of other AR downstream genes, including PSA, TMPRSS2, and PMEPA1. ZC9 promotes Apoptosis. ZC9 exhibits anticancer activity against prostate cancer.
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Eragidomide (Standard)
0 ImagesCat. No.: HY-130800RCAS No.: 1860875-51-9Synonyms: CC-90009 (Standard)Eragidomide (Standard) is the analytical standard of Eragidomide (HY-130800). This product is intended for research and analytical applications. Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation.
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Chloroquinoxaline sulfonamide (Standard)
0 ImagesChloroquinoxaline sulfonamide (Standard) is the analytical standard of Chloroquinoxaline sulfonamide. This product is intended for research and analytical applications. Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle. Antitumor activity.
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Voclosporin (Standard)
0 ImagesSynonyms: ISAtx-247 (Standard)Voclosporin (Standard) is the analytical standard of Voclosporin. This product is intended for research and analytical applications. Voclosporin (ISAtx-247) is a calcineurin (PP2B) (CN) inhibitor.
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NRX-252262 (Standard)
0 ImagesCat. No.: HY-111760RCAS No.: 2438637-61-5NRX-252262 (Standard) is the analytical standard of NRX-252262 (HY-111760). This product is intended for research and analytical applications. NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.
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CC-885 (Standard)
0 ImagesCat. No.: HY-101488RCAS No.: 1010100-07-8CC-885 (Standard) is the analytical standard of CC-885 (HY-101488). This product is intended for research and analytical applications. CC-885, a cereblon (CRBN) modulator, acts as a molecular glue degrader targeting GSPT1 with a Kd of 350 nM. CC-885 binds to CRBN to alter the substrate specificity of the CRL4 E3 ligase, promoting the ubiquitination and proteasomal degradation of GSPT1, BNIP3L, PLK1, CDK4, IKZF1/3, GSPT2, WIZ, CHD7, GOLM1, CK1α and ETS1. CC-885 induces apoptosis, cell cycle arrest, transcriptional downregulation and antiproliferation in cancer cells. CC-885 is applicable to research related to relapsed/refractory acute myeloid leukemia, MYC-driven tumors, metastatic castration-resistant prostate cancer, multiple myeloma, hepatocellular carcinoma, glioblastoma, VHL-deficient clear cell renal cell carcinoma and non-small cell lung cancer.
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WIZ degrader 7
0 ImagesCat. No.: HY-163824CAS No.: 3036553-83-7WIZ degrader 7 (Example 16) is a WIZ molecular glue degrader with an IC50 value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia.
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(S)-VAV1 degrader-1
0 ImagesCat. No.: HY-W1118851CAS No.: 3050683-64-9(S)-VAV1 degrader-1 is a VAV1 molecular glue degrader with DC50 = 3.07 nM. (S)-VAV1 degrader-1 is used for research on VAV1-related diseases, such as inflammation and immune-related diseases.
